Development of High-Throughput substrates for Generating Two-Dimensional Nanoparticles Assemblies and for Screening Protein Adsorption

Abstract

ABSTRACTWe discuss methods leading to the fabrication of orthogonal substrates comprising surface-anchored polymer brushes, in which the polymer brush grafting density and molecular weight vary independently in two mutually perpendicular directions. We demonstrate that these orthogonal polymer substrates can be used as intelligent combinatorial platforms that facilitate the spatial distribution of nanoparticles and allow screening of protein adsorption on surfaces.