Clinicopathological Profile of Oral Squamous Cell Carcinoma in Eastern India

Author:

Senapati Surendra Nath,Samanta Dipti Rani,Avinash Ajitesh,Parida Maitree,Mohanty Sugyan Nandan,Bhuyan Sanat Kumar,Mallik Rabi Narayan

Abstract

Introduction: Head and Neck cancer is most common cancer in developing countries like India. Oral Squamous Cell Carcinoma (OSCC) is the most common site of head and neck malignancy. Various histopathological factors prognosticates the therapeutic outcome. Clinicopathological characteristics of OSCC in Asian countries somehow differ from Western countries. Aim: To report the different clinicopathological characteristics of OSCC due to paucity of the literature even though it is one of the most common malignancy in India. Materials and Methods: In this retrospective observational study, the medical records of 1753 patients of OSCC who satisfied the eligibility criteria and were treated at a tertiary cancer centre at Cuttack, Odisha, India, from January 2009 to December 2019. Clinicopathological profile of the included subjects were noted. The data was analysed in the month of March 2021 using descriptive statistics such as mean, median, maximum, minimum value and percentage using International Business Machine (IBM) Statistical Package for the Social Sciences (SPSS) version 23.0. Results: Total of 1753 patients were analysed with the mean age of 50.55±12.56 years, however, majority 492 (28.1%) were in the age of 40-49 years. Male predominance was observed in 1379 (78.7%) patients. Buccal mucosa was the most common primary site in 731 (41.7%) patients, (41.7%) followed by the tongue in 359 (20.5%) patients. Left side lesion was seen in 1008 (57.5%) patients while 734 (41.9%) patients had lesion at right side. Morphologically, ulceroinfiltrative lesion was the most common presentation constituting in 897 (51.2%) patients. Maximum tumour size was 2.91±1.25 cm. Maximum number of patients i.e., 1529 (87.2%) had grade I disease. Mean Depth of Invasion (DOI) was 8.67±4.50 mm. Lymphovascular Space Invasion (LVI) was positive in 123 (7%) patients and Perineural Invasion (PNI) was observed in 565 (32.2%) patients. Resected margin was positive in 203 (11.6%) patients. Cervical lymph node involvement was found in 691 (39.4%) patients and 28 (1.6%) had extracapsular extension. In the present study, most of the patients presented in advanced stage of the disease i.e., stage III 380 (21.7%) and stage IV 506 (28.9%). Conclusion: The present study highlights that majority of OSCC presents in younger age groups, as left side buccal mucosal lesion with advanced stages of disease. This scenario is due to poor lifestyle pattern which can be prevented by avoidance of tobacco consumption, active screening, public awareness and early diagnosis.

Publisher

JCDR Research and Publications

Subject

Clinical Biochemistry,General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3