Author:
Rawlings-Mortimer Florence,Lazari Alberto,Tisca Cristiana,Tachrount Mohamed,Martins-Bach Aurea B.,Miller Karla L.,Lerch Jason P.,Johansen-Berg Heidi
Abstract
Introduction: 7,8-dihydroxyflavone (7,8-DHF) is a low molecular weight compound that can cross the blood brain barrier and has been implicated in numerous functions and behaviours. It is thought to have neuroprotective capability and has been shown to alleviate symptoms in a wide range of diseases.Methods: 7,8-DHF was administered systemically to wildtype mice during Morris water maze training. Long-term spatial memory was assessed 28 days later. Ex-vivo T2-weighted (T2w) imaging was undertaken on a subset of these mice to assess brain-wide changes in volume.Results: We found that systemic 7,8-DHF administration during the training period enhanced spatial memory 28 days later. Volumetric changes were observed in numerous brain regions associated with a broad range of functions including cognition, sensory, and motor processing.Discussion: Our findings give the first whole brain overview of long-term anatomical changes following 7,8-DHF administration providing valuable information for assessing and understanding the widespread effects this drug has been shown to have in behaviour and disease.
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Developmental Neuroscience,Neuroscience (miscellaneous)
Reference65 articles.
1. Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation;Agrawal;Biochim. Biophys. Acta,2015
2. Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice;Ahuja;Autophagy,2022
3. 7,8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer’s disease by reversing oxidative stress, mitochondrial dysfunction and insulin resistance;Akhtar;Psychopharmacology (Berl),2021
4. Optimized integration of fluoxetine and 7,8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period;Amin;Prog. Neuropsychopharmacol. Biol. Psychiatry,2020
5. 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats;Andero;Hippocampus,2012
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献