Author:
Surolia Ranu,Antony Veena B.
Abstract
Vimentin intermediate filaments, a type III intermediate filament, are among the most widely studied IFs and are found abundantly in mesenchymal cells. Vimentin intermediate filaments localize primarily in the cytoplasm but can also be found on the cell surface and extracellular space. The cytoplasmic vimentin is well-recognized for its role in providing mechanical strength and regulating cell migration, adhesion, and division. The post-translationally modified forms of Vimentin intermediate filaments have several implications in host-pathogen interactions, cancers, and non-malignant lung diseases. This review will analyze the role of vimentin beyond just the epithelial to mesenchymal transition (EMT) marker highlighting its role as a regulator of host-pathogen interactions and signaling pathways for the pathophysiology of various lung diseases. In addition, we will also examine the clinically relevant anti-vimentin compounds and antibodies that could potentially interfere with the pathogenic role of Vimentin intermediate filaments in lung disease.
Funder
National Institute of Environmental Health Sciences
Office of Extramural Research, National Institutes of Health
Subject
Cell Biology,Developmental Biology
Reference229 articles.
1. Bacterial Infections, Alloimmunity, and Transplantation Tolerance;Ahmed;Transplant. Rev.,2011
2. The Prognostic Impact of NF-Κb P105, Vimentin, E-Cadherin and Par6 Expression in Epithelial and Stromal Compartment in Non-small-cell Lung Cancer;Al-Saad;Br. J. Cancer,2008
3. Histones Trigger Sterile Inflammation by Activating the NLRP3 Inflammasome;Allam;Eur. J. Immunol.,2013
4. Alveolar Macrophages in the Resolution of Inflammation, Tissue Repair, and Tolerance to Infection;Allard;Front. Immunol.,2018
5. Rab GTPases-Cargo Direct Interactions: fine Modulators of Intracellular Trafficking;Aloisi;Histol. Histopathol,2013
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献