Author:
Chen Sisi,Geng Xinwei,Syeda Madiha Zahra,Huang Zhengming,Zhang Chao,Ying Songmin
Abstract
MUS81 complex, exhibiting endonuclease activity on specific DNA structures, plays an influential part in DNA repair. Research has proved that MUS81 is dispensable for embryonic development and cell viability in mammals. However, an intricate picture has emerged from studies in which discrepant gene mutations completely alter the role of MUS81 in human cancers. Here, we review the recent understanding of how MUS81 functions in tumors with distinct genetic backgrounds and discuss the potential therapeutic strategies targeting MUS81 in cancer.
Funder
Ministry of Science Research and Technology
Natural Science Foundation of Zhejiang Province
Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents
National Natural Science Foundation of China
Subject
Cell Biology,Developmental Biology
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献