Innovative biomaterials for the treatment of periodontal disease

Author:

Zhu Yi,Tao Chen,Goh Cynthia,Shrestha Annie

Abstract

Periodontitis is a multifactorial disease that involves the destruction of hard and soft tissues surrounding the tooth. Routine periodontal treatment includes mechanical debridement (surgical and non-surgical) and the systemic administration of antibiotics. In contrast, severe and chronic periodontitis involves aggressive tissue destruction and bone resorption, and the damage is usually irreversible. In these severe cases, bone grafts, the delivery of growth hormones, and guided tissue regeneration can all be used to stimulate periodontal regeneration. However, these approaches do not result in consistent and predictable treatment outcomes. As a result, advanced biomaterials have evolved as an adjunctive approach to improve clinical performance. These novel biomaterials are designed to either prolong the release of antibacterial agents or osteogenic molecules, or to act as immunomodulators to promote healing. The first half of this review briefly summarizes the key immune cells and their underlying cellular pathways implicated in periodontitis. Advanced biomaterials designed to promote periodontal regeneration will be highlighted in the second half. Finally, the limitations of the current experimental design and the challenges of translational science will be discussed.

Publisher

Frontiers Media SA

Subject

Applied Mathematics

Reference170 articles.

1. Prevalence of periodontal disease, its association with systemic diseases and prevention;Nazir;Int J Health Sci,2017

2. Periodontitis: a multifaceted disease of tooth-supporting tissues;Könönen;J Clin Med,2019

3. Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis;Herbert;Mol Oral Microbiol,2016

4. Porphyromonas gingivalis: major periodontopathic pathogen overview;Mysak;J Immunol Res,2014

5. Microbial complexes in subgingival plaque;Socransky;J Clin Periodontol,1998

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