Role of integrins in the development of fibrosis in the trabecular meshwork-Reference-Cited by-同舟云学术

Role of integrins in the development of fibrosis in the trabecular meshwork

Published:2023-10-24 Issue: Volume:3 Page:
ISSN:2674-0826
Container-title:Frontiers in Ophthalmology
language:
Short-container-title:Front. Ophthalmol.

Author:

Faralli Jennifer A.,Filla Mark S.,Peters Donna M.

Abstract

Primary open angle glaucoma (POAG) is a progressive and chronic disease exhibiting many of the features of fibrosis. The extracellular matrix (ECM) in the trabecular meshwork (TM) undergoes extensive remodeling and enhanced rigidity, resembling fibrotic changes. In addition, there are changes associated with myofibroblast activation and cell contractility that further drives tissue fibrosis and stiffening. This review discusses what is known about the integrins in the TM and their involvement in fibrotic processes.

Publisher

Frontiers Media SA

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