Author:
Wang Ge,Wu Wenyue,Xu Yuchen,Yang Zhuanyi,Xiao Bo,Long Lili
Abstract
Epilepsy is a neurological network disease with genetics playing a much greater role than was previously appreciated. Unfortunately, the relationship between genetic basis and imaging phenotype is by no means simple. Imaging genetics integrates multidimensional datasets within a unified framework, providing a unique opportunity to pursue a global vision for epilepsy. This review delineates the current knowledge of underlying genetic mechanisms for brain networks in different epilepsy syndromes, particularly from a neural developmental perspective. Further, endophenotypes and their potential value are discussed. Finally, we highlight current challenges and provide perspectives for the future development of imaging genetics in epilepsy.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Key Research and Development Program of Hunan Province of China
Subject
Cellular and Molecular Neuroscience,Molecular Biology
Cited by
1 articles.
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