Author:
Singh Sanjula D.,Rivier Cyprien A.,Papier Keren,Chemali Zeina,Gutierrez-Martinez Leidys,Parodi Livia,Mayerhofer Ernst,Senff Jasper,Clocchiatti-Tuozzo Santiago,Nunley Courtney,Newhouse Amy,Ouyang An,Westover M. Brandon,Tanzi Rudolph E.,Lazar Ronald M.,Pikula Aleksandra,Ibrahim Sarah,Brouwers H. Bart,Howard Virginia J.,Howard George,Yechoor Nirupama,Littlejohns Thomas,Sheth Kevin N.,Rosand Jonathan,Fricchione Gregory,Anderson Christopher D.,Falcone Guido J.
Abstract
IntroductionThe 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by encouraging lifestyle changes. Given that late-life depression is increasingly recognized to share risk factors with stroke and dementia, and is an important clinical endpoint for brain health, we tested the hypothesis that a higher BCS is associated with a reduced incidence of future depression. Additionally, we examined its association with a brain health composite outcome comprising stroke, dementia, and late-life depression.MethodsThe BCS was derived from the United Kingdom Biobank baseline evaluation in participants with complete data on BCS items. Associations of BCS with the risk of subsequent incident late-life depression and the composite brain health outcome were estimated using multivariable Cox proportional hazard models. These models were adjusted for age at baseline and sex assigned at birth.ResultsA total of 363,323 participants were included in this analysis, with a median BCS at baseline of 12 (IQR: 11-14). There were 6,628 incident cases of late-life depression during a median follow-up period of 13 years. Each five-point increase in baseline BCS was associated with a 33% lower risk of incident late-life depression (95% CI: 29%-36%) and a 27% lower risk of the incident composite outcome (95% CI: 24%-30%).DiscussionThese data further demonstrate the shared risk factors across depression, dementia, and stroke. The findings suggest that a higher BCS, indicative of healthier lifestyle choices, is significantly associated with a lower incidence of late-life depression and a composite brain health outcome. Additional validation of the BCS is warranted to assess the weighting of its components, its motivational aspects, and its acceptability and adaptability in routine clinical care worldwide.