Stool Saponified Fatty Acid, Behavior, Growth, and Stool Characteristics in Infants Fed a High-OPO Formula: A Randomized, Double-Blind Clinical Trial

Author:

Shen Lili,Huang Weihua,Xu Xuebing,Wang Li,Wang Qingyun,Li Shengqi,Yuan Xuewei

Abstract

Objective: 1,3-Dioleoyl-2-palmitoylglycerol (OPO) is an ideal structured triglyceride for infant formula, with a similar structure to human milk fat. We conducted this randomized, double-blind controlled, single-center trial to evaluate the effects of an OPO formula in infants.Study Design: One hundred seventy-four healthy term infants <14 days old were assigned to the standard formula-fed group (n = 55), high sn-2 palmitic acid (OPO) formula-fed infants (n = 58), and breastfed (BF) group (n = 61). The primary endpoint was the total saponified fatty acid content in feces at week 6 and week 12.Results: Infants from the OPO group had lower concentrations of fecal saponified fatty acids than those from the standard formula group (p < 0.0001) at week 6 and week 12. The frequencies of crying per day and per night of infants in the OPO group were significantly less than those of infants in the standard formula group (p < 0.0001). After 12 weeks of feeding, the length of infants was significantly higher in the OPO group than in the other two groups (p = 0.002). Infants in the OPO group had a significantly lower stool calcium concentration and a higher stool frequency per day than infants in the standard formula group.Conclusion: In summary, a high concentration of OPO in formula is beneficial to the growth and development of infants.

Publisher

Frontiers Media SA

Subject

Pediatrics, Perinatology, and Child Health

Reference35 articles.

1. Breast milk nutrient content and infancy growth;Prentice;Acta Paediatr.,2016

2. De novo synthesis of milk triglycerides in humans;Mohammad;Am J Physiol Endocrinol Metab.,2014

3. Model for human milk fat substitute evaluation based on triacylglycerol composition profile;Zou;J Agric Food Chem.,2013

4. Lipid quality in infant nutrition: current knowledge and future opportunities;Delplanque;J Pediatr Gastroenterol Nutr.,2015

5. Review of sn-2 palmitate oil implications for infant health;Bar-Yoseph;Prostaglandins Leukot Essent Fatty Acids.,2013

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3