Author:
Li Dan,Long Yu,Yu Shuang,Shi Ai,Wan Jinyan,Wen Jing,Li Xiaoqiu,Liu Songyu,Zhang Yulu,Li Nan,Zheng Chuan,Yang Ming,Shen Lin
Abstract
Cardio-cerebrovascular diseases (CVDs) are a serious threat to human health and account for 31% of global mortality. Ligusticum chuanxiong Hort. (CX) is derived from umbellifer plants. Its rhizome, leaves, and fibrous roots are similar in composition but have different contents. It has been used in Japanese, Korean, and other traditional medicine for over 2000 years. Currently, it is mostly cultivated and has high safety and low side effects. Due to the lack of a systematic summary of the efficacy of CX in the treatment of CVDs, this article describes the material basis, molecular mechanism, and clinical efficacy of CX, as well as its combined application in the treatment of CVDs, and has been summarized from the perspective of safety. In particular, the pharmacological effect of CX in the treatment of CVDs is highlighted from the point of view of its mechanism, and the complex mechanism network has been determined to improve the understanding of CX’s multi-link and multi-target therapeutic effects, including anti-inflammatory, antioxidant, and endothelial cells. This article offers a new and modern perspective on the impact of CX on CVDs.
Funder
Chengdu University of Traditional Chinese Medicine
State Administration of Traditional Chinese Medicine of the People’s Republic of China
Jiangxi Provincial Department of Science and Technology
Department of Science and Technology of Sichuan Province
Subject
Pharmacology (medical),Pharmacology
Cited by
24 articles.
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