Author:
Bibi Salma,Khan Amjad,Khan Amer Hayat,Khan Muhammad Niaz,Mushtaq Saima,Rashid Sheikh Abdur
Abstract
Background: Biodegradable polymer (BP) drug-eluting stents (DES) have been introduced as a novel solution to the problems of durable polymer (DP) stents. In Pakistan, very few studies are available for the treatment intervention in post-primary percutaneous coronary intervention (PPCI) patients. Our study will compare the major adverse cardiovascular events (MACEs) and their predictors in patients with coronary artery disease (CAD) undergoing PPCI with second- or third-generation DES.Methodology: An observational, retrospective, cohort study was carried out on CAD patients undergoing PPCI with either second- (DP-XIENCE Prime/XIENCE Xpedition) or third-generation (BP-BioMatrix NeoFlex/BioMatrix Alpha) DES. MACEs were assessed after 1 year of PPCI procedure in 341 patients and screened as per inclusion/exclusion criteria (167 in the second-generation group and 174 in the third-generation group).Results: The number of male patients (86.2%) was more than female patients in our study population. MACEs were reported in 4.19% patients after 1 year duration, and the percentage of MACEs was more in the second-generation DES group (4.77%) than in the third-generation group (3.44%); however, statistical analysis has not found any significant difference (p = 0.534). The rate of myocardial infarction (1.19% vs. 0.57%) and stent thrombosis (1.8% vs. 1.15%) was more in the second-generation DES group. However, restenosis (1.19% vs. 1.15%) and cardiac death (0.59% vs. 0.57%) were almost same in both groups. A significant association was found between MACEs and diabetes mellitus (p = 0.025), hypertension (p = 0.035), smoking (p = 0.008), and a family history of CAD (p = 0.018).Conclusion: BP-BioMatrix and DP-XIENCE DES have comparable clinical outcomes. Findings of the current study will assist the policy makers and healthcare providers in the rationalization of scarce resources and evidence-based patient care. However, longer follow-up studies are required for convincing results.
Subject
Pharmacology (medical),Pharmacology
Reference49 articles.
1. Xience prime and xience prime LL everolimus Eluting Coronary Stents System [Online]2015
2. XIENCE xpedition, xience xpeion SV, and XIENCE xpedition LL everolimus eluting Stent System [Online]2013
3. One year outcomes after percutaneous coronary intervention in diabetics with stable ischemic heart disease: A single-center comparative study;Adil;Hypertension,2021
4. Impact of smoking status on short term clinical outcomes of drug eluting stents in patients with stable coronary artery disease;Adnan;Pak. Heart J.,2017
5. Predictors of long-term major adverse cardiac events following percutaneous coronary intervention in the elderly;Aghajani;Arch. Iran. Med.,2018
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