Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR-Reference-Cited by-同舟云学术

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Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR

Published:2020-09-17 Issue: Volume:11 Page:
ISSN:1663-9812
Container-title:Frontiers in Pharmacology
language:
Short-container-title:Front. Pharmacol.

Author:

Duan Ya-bin,Zhu Jun-bo,Yang Jian-xin,Liu Gui-qin,Bai Xue,Qu Ning,Wang Xue-jun,Li Xiang-yang

Funder

National Natural Science Foundation of China

Natural Science Foundation of Qinghai

Publisher

Frontiers Media SA

Subject

Pharmacology (medical),Pharmacology

Reference43 articles.

1. Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors;Akiyama;Biochim. Biophys. Acta,2003

2. Effect of intermittent hypobaric hypoxia on efficacy and clearance of drug;Anjana;Indian J. Med. Res.,2012

3. Regulation of Liver Enriched Transcription Factors in Rat Hepatocytes Cultures on Collagen and EHS Sarcoma Matrices;Borlak;PloS One,2015

4. Establishment of cytochrome P450 3A4 and glutathione S-transferase A1-transfected human hepatoma cell line and functional analysis;Chang;Gene Mol. Res.,2014

5. Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity;Chang;Phytomedicine,2017

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1. Blood–Brain Barrier Permeability is Affected by Changes in Tight Junction Protein Expression at High-Altitude Hypoxic Conditions—this may have Implications for Brain Drug Transport;The AAPS Journal;2024-08-06

2. Effects of High-altitude Hypoxia on Drug Metabolism and Pharmacokinetics of Sedative-hypnotic Drugs and Regulatory Mechanism;Current Drug Metabolism;2024-08-06

3. Altitude effect on Propofol Pharmacokinetics in Rats;Current Drug Metabolism;2024-01

4. Effect of High Altitude Environment on Pharmacokinetic and Pharmacodynamic of Warfarin in Rats;Current Drug Metabolism;2024-01

5. Cytochrome P450 enzyme-based biotransformation of pharmaceuticals and personal care products (PPCPs) by microalgae in the aquatic environment;Chemical Engineering Journal;2023-11

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