Author:
Ferreira Jacob,Levin Lonny R.,Buck Jochen
Abstract
In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY10). This review details why sAC is uniquely druggable and outlines ways to target sAC for novel forms of male and female contraception.
Funder
National Institutes of Health
United States Agency for International Development
Subject
Pharmacology (medical),Pharmacology
Cited by
12 articles.
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