Author:
Mondal Banashree,Choudhury Supriyo,Banerjee Rebecca,Roy Akash,Chatterjee Koustav,Basu Purba,Singh Ravi,Halder Saptak,Shubham Shantanu,Baker Stuart N.,Baker Mark R.,Kumar Hrishikesh
Abstract
Non-invasive vagus nerve stimulation (nVNS) is an established neurostimulation therapy used in the treatment of epilepsy, migraine and cluster headache. In this randomized, double-blind, sham-controlled trial we explored the role of nVNS in the treatment of gait and other motor symptoms in Parkinson’s disease (PD) patients. In a subgroup of patients, we measured selected neurotrophins, inflammatory markers and markers of oxidative stress in serum. Thirty-three PD patients with freezing of gait (FOG) were randomized to either active nVNS or sham nVNS. After baseline assessments, patients were instructed to deliver six 2 min stimulations (12 min/day) of the active nVNS/sham nVNS device for 1 month at home. Patients were then re-assessed. After a one-month washout period, they were allocated to the alternate treatment arm and the same process was followed. Significant improvements in key gait parameters (speed, stance time and step length) were observed with active nVNS. While serum tumor necrosis factor- α decreased, glutathione and brain-derived neurotrophic factor levels increased significantly (p < 0.05) after active nVNS treatment. Here we present the first evidence of the efficacy and safety of nVNS in the treatment of gait in PD patients, and propose that nVNS can be used as an adjunctive therapy in the management of PD patients, especially those suffering from FOG.Clinical trial registration: identifier ISRCTN14797144.
Reference60 articles.
1. Parkinson’s disease: a systemic inflammatory disease accompanied by bacterial inflammagens;Adams;Front. Aging Neurosci.,2019
2. Inflammation and Alzheimer’s disease;Akiyama;Neurobiol. Aging,2000
3. Mitochondria, oxidative damage, and inflammation in Parkinson’s disease;Beal;Ann. N Y Acad. Sci.,2003
4. Controlling the false discovery rate: a practical and powerful approach to multiple testing;Benjamini;J. R. Stat. Soc., Ser. B, Methodol.,1995
5. Surgically implanted and non-invasive vagus nerve stimulation: a review of efficacy, safety and tolerability;Ben-Menachem;Eur. J. Neurol.,2015
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献