Author:
Huang Yaqian,Lu Manli,Wang Yi,Zhang Chunyuan,Cao Yongjun,Zhang Xia
Abstract
As a specific lymphatic marker and a key ligand of C-type lectin-like receptor 2 (CLEC-2), podoplanin (Pdpn) is involved in various physiological and pathological processes such as growth and development, respiration, blood coagulation, lymphangiogenesis, angiogenesis, and inflammation. Thrombotic diseases constitute a major cause of disability and mortality in adults, in which thrombosis and inflammation play a crucial role. Recently, increasing evidence demonstrates the distribution and function of this glycoprotein in thrombotic diseases such as atherosclerosis, ischemic stroke, venous thrombosis, ischemic-reperfusion injury (IRI) of kidney and liver, and myocardial infarction. Evidence showed that after ischemia, Pdpn can be acquired over time by a heterogeneous cell population, which may not express Pdpn in normal conditions. In this review, the research progresses in understanding the roles and mechanisms of podoplanin in thromobotic diseases are summarized. The challenges of podoplanin-targeted approaches for disease prognosis and preventions are also discussed.
Subject
Neurology (clinical),Neurology
Reference101 articles.
1. Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium;Zimmer;Biochem J.,1999
2. Purification and characterization of the platelet-aggregating sialoglycoprotein gp44 expressed by highly metastatic variant cells of mouse colon adenocarcinoma 26;Toyoshima;Cancer Res.,1995
3. Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells;Nose;Cell Growth Differ.,1990
4. Induction of PA2.26, a cell-surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis;Gandarillas;Mol Carcinog.,1997
5. Podoplanin-expressing cells derived from bone marrow play a crucial role in postnatal lymphatic neovascularization;Lee;Circulation.,2010