In Vivo Reductionist Approach Identifies miR-15a Protecting Mice From Obesity

Author:

Murgia Nicola,Ma Yuan,Najam Syeda Sadia,Liu Yu,Przybys Joanna,Guo Chenkai,Konopka Witold,Vinnikov Ilya A.

Abstract

Obesity is a growing medical and social problem worldwide. The control of energy homeostasis in the brain is achieved by various regions including the arcuate hypothalamic nucleus (ARH). The latter comprises a number of neuronal populations including the first order metabolic neurons, appetite-stimulating agouti-related peptide (AgRP) neurons and appetite-suppressing proopiomelanocortin (POMC) neurons. Using an in vivo reductionist approach and POMCCre-dependent CRISPR-Cas9, we demonstrate that miR-15a-5p protects from obesity. Moreover, we have identified Bace1, a gene previously linked to energy metabolism imbalance, as a direct target of miR-15a-5p. This work warrants further investigations of non-coding RNA-mediated regulation of energy homeostasis and might contribute to the development of novel therapeutic approaches to treat metabolic diseases.

Funder

National Natural Science Foundation of China

Shanghai Jiao Tong University

Narodowe Centrum Nauki

Publisher

Frontiers Media SA

Subject

Endocrinology, Diabetes and Metabolism

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