Author:
Li Qiu-Xuan,Gao Han,Guo Yue-Xin,Wang Bo-Ya,Hua Rong-xuan,Gao Lei,Shang Hong-Wei,Lu Xin,Xu Jing-Dong
Abstract
GLP-1 is derived from intestinal L cells, which takes effect through binding to GLP-1R and is inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4). Since its discovery, GLP-1 has emerged as an incretin hormone for its facilitation in insulin release and reduction of insulin resistance (IR). However, GLP-1 possesses broader pharmacological effects including anti-inflammation, neuro-protection, regulating blood pressure (BP), and reducing lipotoxicity. These effects are interconnected to the physiological and pathological processes of Alzheimer’s disease (AD), hypertension, and non-alcoholic steatohepatitis (NASH). Currently, the underlying mechanism of these effects is still not fully illustrated and a better understanding of them may help identify promising therapeutic targets of AD, hypertension, and NASH. Therefore, we focus on the biological characteristics of GLP-1, render an overview of the mechanism of GLP-1 effects in diseases, and investigate the potential of GLP-1 analogues for the treatment of related diseases in this review.
Funder
Foundation for Innovative Research Groups of the National Natural Science Foundation of China
National Key Research and Development Program of China
Subject
Endocrinology, Diabetes and Metabolism
Cited by
29 articles.
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