A systematic review and meta-analysis of proteomic and metabolomic alterations in anaphylaxis reactions

Author:

Gallizzi Adrienne Astrid,Heinken Almut,Guéant-Rodriguez Rosa-Maria,Guéant Jean-Louis,Safar Ramia

Abstract

BackgroundAnaphylaxis manifests as a severe immediate-type hypersensitivity reaction initiated through the immunological activation of target B-cells by allergens, leading to the release of mediators. However, the well-known underlying pathological mechanisms do not fully explain the whole variety of clinical and immunological presentations. We performed a systemic review of proteomic and metabolomic studies and analyzed the extracted data to improve our understanding and identify potential new biomarkers of anaphylaxis.MethodsProteomic and metabolomic studies in both human subjects and experimental models were extracted and selected through a systematic search conducted on databases such as PubMed, Scopus, and Web of Science, up to May 2023.ResultsOf 137 retrieved publications, we considered 12 for further analysis, including seven on proteome analysis and five on metabolome analysis. A meta-analysis of the four human studies identified 118 proteins with varying expression levels in at least two studies. Beside established pathways of mast cells and basophil activation, functional analysis of proteomic data revealed a significant enrichment of biological processes related to neutrophil activation and platelet degranulation and metabolic pathways of arachidonic acid and icosatetraenoic acid. The pathway analysis highlighted also the involvement of neutrophil degranulation, and platelet activation. Metabolome analysis across different models showed 13 common metabolites, including arachidonic acid, tryptophan and lysoPC(18:0) lysophosphatidylcholines.ConclusionOur review highlights the underestimated role of neutrophils and platelets in the pathological mechanisms of anaphylactic reactions. These findings, derived from a limited number of publications, necessitate confirmation through human studies with larger sample sizes and could contribute to the development of new biomarkers for anaphylaxis.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024506246.

Publisher

Frontiers Media SA

Reference54 articles.

1. Time to revisit the definition and clinical criteria for anaphylaxis;Turner;World Allergy Organ J,2019

2. Gell and Coombs’s classification: is it still valid;Descotes;Toxicology,2001

3. Anaphylaxis–a practice parameter update 2015;Lieberman;Ann Allergy Asthma Immunol,2015

4. Epidemiology of anaphylaxis;Tejedor Alonso;Clin Exp Allergy,2015

5. Epidemiology of anaphylaxis;Lieberman;Curr Opin Allergy Clin Immunol,2008

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3