Author:
Lu Yikai,Zhao Mengmeng,Chen Li,Wang Yan,Liu Tianhao,Liu Haipeng
Abstract
As a canonical cytoplasmic DNA sensor, cyclic GMP-AMP synthase (cGAS) plays a key role in innate immunity. In recent years, a growing number of studies have shown that cGAS can also be located in the nucleus and plays new functions such as regulating DNA damage repair, nuclear membrane repair, chromosome fusion, DNA replication, angiogenesis and other non-canonical functions. Meanwhile, the mechanisms underlying the nucleo-cytoplasmic transport and the regulation of cGAS activation have been revealed in recent years. Based on the current understanding of the structure, subcellular localization and canonical functions of cGAS, this review focuses on summarizing the mechanisms underlying nucleo-cytoplasmic transport, activity regulation and non-canonical functions of cGAS in the nucleus. We aim to provide insights into exploring the new functions of cGAS in the nucleus and advance its clinical translation.
Funder
National Natural Science Foundation of China
Beijing Xisike Clinical Oncology Research Foundation
Shanghai Shuguang Program
Shanghai Rising-Star Program
China Postdoctoral Science Foundation
Postdoctoral Innovation Project of Shandong Province
Cited by
2 articles.
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