Author:
Combemale Loraine,Bohelay Gérôme,Sitbon Ishaï-Yaacov,Ahouach Btisseme,Alexandre Marina,Martin Antoine,Pascal Francis,Soued Isaac,Doan Serge,Morin Florence,Grootenboer-Mignot Sabine,Caux Frédéric,Prost-Squarcioni Catherine,Le Roux-Villet Christelle
Abstract
BackgroundLichen planus pemphigoides (LPP), an association between lichen planus and bullous pemphigoid lesions, is a rare subepithelial autoimmune bullous disease. Mucous membrane involvement has been reported previously; however, it has never been specifically studied.MethodsWe report on 12 cases of LPP with predominant or exclusive mucous membrane involvement. The diagnosis of LPP was based on the presence of lichenoid infiltrates in histology and immune deposits in the basement membrane zone in direct immunofluorescence and/or immunoelectron microscopy. Our systematic review of the literature, performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, highlights the clinical and immunological characteristics of LPP, with or without mucous membrane involvement.ResultsCorticosteroids are the most frequently used treatment, with better outcomes in LPP with skin involvement alone than in that with mucous membrane involvement. Our results suggest that immunomodulators represent an alternative first-line treatment for patients with predominant mucous membrane involvement.
Reference55 articles.
1. Lichen ruber pemphigoides;Kaposi;Arch J Dermatol Syph,1892
2. Coexistence of lichen planus and bullous pemphigoid. A immunopathological study;Stingl;Br J Dermatol,1975
3. Lichen plan pemphigoïde [Lichen planus pemphigoides];Cognat;Ann Dermatol Venereol,1991
4. Ramipril-associated lichen planus pemphigoides;Ogg;Br J Dermatol,1997
5. Autoantibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16A domain of BP180;Zillikens;J Invest Dermatol,1999