Author:
Fukui Chihiro,Yamana Satoshi,Xue Yanqi,Shirane Mariko,Tsutsui Hiroki,Asahara Kenichiro,Yoshitomi Keiko,Ito Takako,Lestari Tantri,Hasegawa Eiichi,Yawata Nobuyo,Takeda Atsunobu,Sonoda Koh-Hei,Shibata Kensuke
Abstract
Mucosal-associated invariant T (MAIT) cells are a unique subset of T cells that recognizes metabolites derived from the vitamin B2 biosynthetic pathway. Since the identification of cognate antigens for MAIT cells, knowledge of the functions of MAIT cells in cancer, autoimmunity, and infectious diseases has been rapidly expanding. Recently, MAIT cells have been found to contribute to visual protection against autoimmunity in the eye. The protective functions of MAIT cells are induced by T-cell receptor (TCR)-mediated activation. However, the underlying mechanisms remain unclear. Thus, this mini-review aims to discuss our findings and the complexity of MAIT cell-mediated immune regulation in the eye.
Reference73 articles.
1. Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye;Medawar;Br J Exp Pathol,1948
2. Blood-retinal barrier;Cunha-Vaz;Eur J Ophthalmol,2011
3. APCs in the anterior uveal tract do not migrate to draining lymph nodes;Dullforce;J Immunol,2004
4. Ocular autoimmunity: the price of privilege;Caspi;Immunol Rev,2006
5. Do immunologically privileged sites require a functioning spleen;Kaplan;Nature,1974