Author:
Vannella Kevin M.,Oguz Cihan,Stein Sydney R.,Pittaluga Stefania,Dikoglu Esra,Kanwal Arjun,Ramelli Sabrina C.,Briese Thomas,Su Ling,Wu Xiaolin,Ramos-Benitez Marcos J.,Perez-Valencia Luis J.,Babyak Ashley,Cha Nu Ri,Chung Joon-Yong,Ylaya Kris,Madathil Ronson J.,Saharia Kapil K.,Scalea Thomas M.,Tran Quincy K.,Herr Daniel L.,Kleiner David E.,Hewitt Stephen M.,Notarangelo Luigi D.,Grazioli Alison,Chertow Daniel S.
Abstract
A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and tissue-repair macrophages. Myocardial T-cell receptor (TCR) sequencing revealed hyper-dominant clones with highly similar sequences to TCRs that are specific for SARS-CoV-2 epitopes. SARS-CoV-2 RNA was detected in the gut, supporting a diagnosis of multisystem inflammatory syndrome in adults (MIS-A). Molecular targets of MIS-associated inflammation are not known. Our data indicate that SARS-CoV-2 antigens selected high-frequency T-cell clones that mediated fatal myocarditis.
Funder
Division of Intramural Research, National Institute of Allergy and Infectious Diseases
NIH Clinical Center
Subject
Immunology,Immunology and Allergy
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献