Author:
Mullaney Jane A.,Roy Nicole C.,Halliday Christine,Young Wayne,Altermann Eric,Kruger Marlena C.,Dilger Ryan N.,McNabb Warren C.
Abstract
The gastrointestinal (GI) microbiota has co-evolved with the host in an intricate relationship for mutual benefit, however, inappropriate development of this relationship can have detrimental effects. The developing GI microbiota plays a vital role during the first 1,000 days of postnatal life, during which occurs parallel development and maturation of the GI tract, immune system, and brain. Several factors such as mode of delivery, gestational age at birth, exposure to antibiotics, host genetics, and nutrition affect the establishment and resultant composition of the GI microbiota, and therefore play a role in shaping host development. Nutrition during the first 1,000 days is considered to have the most potential in shaping microbiota structure and function, influencing its interactions with the immune system in the GI tract and consequent impact on brain development. The importance of the microbiota-GI-brain (MGB) axis is also increasingly recognized for its importance in these developmental changes. This narrative review focuses on the importance of the GI microbiota and the impact of nutrition on MGB axis during the immune system and brain developmental period in early postnatal life of infants.
Subject
Microbiology (medical),Microbiology
Reference178 articles.
1. Diverse galactooligosaccharides consumption by bifidobacteria: implications of β-galactosidase–LacS operon;Akiyama;Biosci. Biotechnol. Biochem.,2015
2. Assessment of fecal bacterial diversity among healthy piglets during the weaning transition;Alain;J. Gen. Appl. Microbiol.,2014
3. Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C;Al-Qudah;Am. J. Physiol. Gastrointest. Liver Physiol.,2014
4. Route of lymphocyte migration in pigs. I. Lymphocyte circulation in gut-associated lymphoid tissue;Bennell;Immunology
5. Route of lymphocyte migration in pigs. II. Migration to the intestinal lamina propria of antigen-specific cells generated in response to intestinal immunization in the pig;Bennell;Immunology
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