Neuroprotective expression of turmeric and curcumin

Abstract

Turmeric (Curcuma longa) is extensively used as a spice and a coloring agent in Southeast Asia. Turmeric is used as a traditional remedy for cough, diabetic wounds, hepatic disorders, and rheumatism due to its antiseptic, antibacterial, and anti-inflammatory properties. Since the last few decades, extensive work has been done on turmeric and its constituents to explore its pharmacological actions. Curcumin is the main constituent of turmeric and is well demonstrated for its anti-inflammatory, hypoglycaemic, antioxidant, wound-healing, and antimicrobial activities. The functional neurons of the brain and synapses are lost in neurodegenerative disorders for which there is no permanent cure. Oxidative damage and inflammation play a role in age-related neurological disorders. The antioxidants have the ability to prevent different neurological disorders. Recent studies have shown that both turmeric and curcumin possess neuroprotective and cognitiveenhancing properties that help to prevent neurodegenerative diseases like Alzheimer's disease and Parkinson’s disease. Different experimental studies have indicated the antioxidant and anti-ageing properties of turmeric and curcumin. Various studies have shown that curcumin acts as a strong barrier against neurological disorders and, hence, it may be a potential drug candidate for the prevention of neurodegenerative diseases. The aim of this review was to present the current pieces of evidence in the literature regarding the neuroprotective effects of turmeric and curcumin.