Quantitative magnetic resonance imaging (qMRI) in axial spondyloarthritis

Author:

Thorley Natasha1ORCID,Jones Alexis2,Ciurtin Coziana2,Castelino Madhura2,Bainbridge Alan3,Abbasi Maaz1,Taylor Stuart4,Zhang Hui5,Hall-Craggs Margaret A.4,Bray Timothy J.P.4

Affiliation:

1. Imaging Department, University College London Hospitals NHS Foundation Trust, London, United Kingdom

2. Department of Rheumatology, University College London Hospitals NHS Foundation Trust, London, United Kingdom

3. Department of Medical Physics, University College London Hospitals, London, United Kingdom

4. Centre for Medical Imaging (CMI), University College London, London, United Kingdom

5. Department of Computer Science and Centre for Medical Image Computing, University College London, London, United Kingdom

Abstract

Imaging, and particularly MRI, plays a crucial role in the assessment of inflammation in rheumatic disease, and forms a core component of the diagnostic pathway in axial spondyloarthritis. However, conventional imaging techniques are limited by image contrast being non-specific to inflammation and a reliance on subjective, qualitative reader interpretation. Quantitative MRI methods offer scope to address these limitations and improve our ability to accurately and precisely detect and characterise inflammation, potentially facilitating a more personalised approach to management. Here, we review quantitative MRI methods and emerging quantitative imaging biomarkers for imaging inflammation in axial spondyloarthritis. We discuss the potential benefits as well as the practical considerations that must be addressed in the movement toward clinical translation of quantitative imaging biomarkers.

Publisher

Oxford University Press (OUP)

Subject

Radiology, Nuclear Medicine and imaging,General Medicine

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