First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma

Author:

Tran Maxine12,Latifoltojar Arash3,Neves Joana B.12,Papoutsaki Marianthi-Vasiliki3,Gong Fiona3,Comment Arnaud4,Costa Ana S. H.5,Glaser Matthias67,Tran-Dang My-Anh8,El Sheikh Soha8,Piga Wivijin3,Bainbridge Alan9,Barnes Anna36,Young Tim5,Jeraj Hassan3,Awais Ramla67,Adeleke Sola3,Holt Christopher10,O’Callaghan James3,Twyman Frazer6,Atkinson David3,Frezza Christian5,Årstad Erik67,Gadian David11,Emberton Mark1213,Punwani Shonit314

Affiliation:

1. Research Department of Surgical Biotechnology, Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London, UK

2. Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK

3. Centre for Medical Imaging, Division of Medicine, University College London, UK

4. General Electric Healthcare, Chalfont St Giles, UK

5. Medical Research Council Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, UK

6. Institute of Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, UK

7. Department of Chemistry, University College London, UK

8. Department of Histopathology, Royal Free London NHS Foundation Trust, London, UK

9. Department of Medical Physics and Biomedical Engineering, University College London Hospitals NHS Foundation Trust, London, UK

10. Pharmacy Department, University College London Hospitals NHS Foundation Trust, London, UK

11. Institute of Child Health, University College London, London, UK

12. Faculty of Medical Sciences, School of Life and Medical Sciences, University College London, UK

13. Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK

14. Department of Radiology, University College London Hospitals NHS Foundation Trust, London, UK

Abstract

Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been explored. We report on the first-in-human in vivo non-invasive metabolic interrogation of renal cell carcinoma using hyperpolarized carbon-13 (13C) MRI and describe the validation of in vivo lactate metabolic heterogeneity against multi regional ex vivo mass spectrometry. hyperpolarized carbon-13 (13C)-MRI provides an in vivo assessment of metabolism and provides a novel opportunity to safely and non-invasively assess cancer heterogeneity.

Publisher

British Institute of Radiology

Subject

Pharmacology (medical),Complementary and alternative medicine,Pharmaceutical Science

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