Investigations of Sedative and Antidiarrheal Activity of Commelina appendiculata in Swiss Albino Mice

Abstract

The aim of the present study was to investigate the sedative and antidiarrheal activity of ethanol extract ofC. appendiculataat the doses of 100 and 200 mg/kg body weight per oral (p.o) inSwiss albinomice. Sedative activity of the extract (100 and 200 mg/kg, p.o.) was assessed utilizing thiopental sodium-induced sleeping time model to evaluate sedative potential of the extract, hole cross to evaluate motor activity and open field test to evaluate exploratory behaviour. The extract also produced rapid onset and maximized the duration of sleeping time when administered with thiopental sodium. The extract fundamentally (p < 0.05-0.001) diminished motor action and exploratory conduct of mice in hole cross and open field test separately. In antidiarreal activity study, the concentrate (200 mg/kg) likewise demonstrated most extreme inhibition of defecation (90.64% and 80.95%) in both models individually. The present study demonstrates that the ethanol extract ofC. appendiculatahave central nervous system (CNS) depressant and antidiarrheal properties. In this manner, the plant may be further investigated to find for its pharmacological active natural products.