1. Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PT, UK
2. Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK
3. Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Oxford Road, Manchester M13 9WL, UK
4. The Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK
5. Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, D04 V1W8 Dublin, Ireland