1. Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
2. National Institute for Health and Care Research (NIHR), Newcastle Biomedical Research Centre (BRC), Newcastle University, Newcastle upon Tyne NE4 5PL, UK
3. Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
4. Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA
5. The Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK
6. Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4AX, UK