Comprehensive Review of Cyclamen: Development, Bioactive Properties, and Therapeutic Applications

Author:

Sharara Aya1,Badran Adnan2,Hijazi Akram1ORCID,Albahri Ghosoon1ORCID,Bechelany Mikhael34ORCID,Mesmar Joelle Edward5ORCID,Baydoun Elias5

Affiliation:

1. Plateforme de Recherche et D’Analyse en Sciences de L’Environnement (EDST-PRASE), Beirut P.O. Box 6573/14, Lebanon

2. Department of Nutrition, University of Petra, Amman P.O. Box 961343, Jordan

3. Institut Européen des Membranes, IEM, UMR-5635, University Montpellier, ENSCM, CNRS, Place Eugene Bataillon, 34095 Montpellier, France

4. Functional Materials Group, Gulf University for Science and Technology (GUST), Mubarak Al-Abdullah 32093, Kuwait

5. Department of Biology, American University of Beirut, Beirut P.O. Box 110236, Lebanon

Abstract

Plants are being researched as potential sources of novel drugs, which has led to a recent acceleration in the discovery of new bioactive compounds. Research on tissue culture technology for the synthesis and processing of plant compounds has skyrocketed, surpassing all expectations. These plants can be bought either raw or as extracts, where some of the chemicals are extracted by mashing the plant in water, alcohol, or another solvent. The use of herbal medicine may open new chances for reducing the onset of infections and treating different diseases including cancer. A perennial plant that blooms in the winter, Cyclamen, is one of the most widely used potted flowers in many nations. Alkaloids, flavonoids, phenols, tannins, saponins, sterols, and glycosides are the main active components of Cyclamen. Analgesic, cytotoxic, antioxidant, antimicrobial, and anti-inflammatory properties have all been demonstrated as potential effects of various extracts of Cyclamen tubers. However, the use of this medicinal plant in official medicine will require further research in the areas of pharmacology. Furthermore, it is necessary to create standard operating procedures for a crude herbal medication. In this regard, this review aims to highlight the key characteristics of the Cyclamen plant, such as its various parts, species, stages of development, and geographic range; pinpoint its intriguing bioactivities, its antioxidant, anti-inflammatory, and its anti-cancerous effects; and ascertain its potential medicinal uses and the main future perspectives.

Publisher

MDPI AG

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