Clostridioides difficile Infection in the Elderly: Trend Analysis from 2000 to 2019-Reference-Cited by-同舟云学术

Clostridioides difficile Infection in the Elderly: Trend Analysis from 2000 to 2019

Published:2024-06-26 Issue:13 Volume:13 Page:3740
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Danpanichkul Pojsakorn¹²,Duangsonk Kwanjit³,Uawithya Ekdanai⁴^ORCID,Kongarin Siwanart⁵,Simadibrata Daniel M.⁶⁷,Polpichai Natchaya⁸^ORCID,Suenghataiphorn Thanathip⁹^ORCID,Wattanachayakul Phuuwadith¹⁰,Pang Yanfang¹¹¹²,Sukphutanan Banthoon⁵,Kaewdech Apichat¹³^ORCID,Panpradist Nuttada¹⁴^ORCID,Chaiyakunapruk Nathorn¹⁵¹⁶^ORCID,Pupaibool Jakrapun¹⁷^ORCID,Wijarnpreecha Karn¹⁸¹⁹²⁰^ORCID

Affiliation:

1. Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

2. Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand

3. Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand

4. Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand

5. Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand

6. Faculty of Medicine, Universitas Indonesia, Depok 16424, Indonesia

7. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA

8. Department of Internal Medicine, Weiss Memorial Hospital, Chicago, IL 60640, USA

9. Department of Internal Medicine, Griffin Hospital, Derby, CT 06460, USA

10. Department of Medicine, Albert Einstein Healthcare Network, Philadelphia, PA 19144, USA

11. Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China

12. National Immunological Laboratory for Traditional Chinese Medicine, Baise 533000, Guangxi, China

13. Gastroenterology and Hepatology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand

14. Global Center for Integrated Health for Women, Adolescents, and Children (Global WACh), Department of Global Health, University of Washington, Seattle, WA 98195, USA

15. Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA

16. IDEAS Center, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, UT 84148, USA

17. Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84113, USA

18. Division of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Phoenix, AZ 85004, USA

19. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Banner University Medical Center, Phoenix, AZ 85724, USA

20. BIO5 Institute, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA

Abstract

Background/Objective: Clostridioides difficile infection (CDI) is a common healthcare-associated ailment, presenting major health and economic challenges, especially for the elderly. Despite its prevalence, comprehensive data about CDI’s impact on the elderly are limited. Methods: This study used the Global Burden of Disease Study 2019 data to analyze CDI trends from 2000 to 2019, considering factors like sex, region, and sociodemographic index (SDI). Results: This study revealed that CDI caused approximately 18,181 deaths and 252,709 disability-adjusted life years (DALYs) among the elderly worldwide. The Americas showed the highest CDI burden, while the Eastern Mediterranean saw the steepest rate increase from 2000 to 2019. Regions with a high SDI also displayed substantial CDI impact. Conclusions: The escalating burden of CDI in the elderly, especially in high-SDI areas and the Americas, emphasizes an urgent need for targeted public health strategies.

Publisher

MDPI AG

Link

https://www.mdpi.com/2077-0383/13/13/3740/pdf

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