Affiliation:
1. Ufa Federal Research Center of RAS, Institute of Petrochemistry and Catalysis, 450075 Ufa, Russia
2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia
Abstract
An efficient method for the synthesis of 3-(1H-indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) via condensation of 7,8,10,12,13-pentaoxaspiro[5.7]tridecane with tryptophan under the action of a catalyst based on Sm(NO3)3·6H2O has been developed. A high cytotoxic activity of eight-membered azadiperoxide against tumor cells Jurkat, K562, U937, and HL60 was established. Additionally, this compound is an inducer of apoptosis and affects the cell cycle.
Funder
Russian Science Foundation
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
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