Vector Competence for Zika Virus Changes Depending on the Aedes aegypti’s Region of Origin in Manaus: A Study of an Endemic Brazilian Amazonian City-Reference-Cited by-同舟云学术

Vector Competence for Zika Virus Changes Depending on the Aedes aegypti’s Region of Origin in Manaus: A Study of an Endemic Brazilian Amazonian City

Published:2023-03-17 Issue:3 Volume:15 Page:770
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

da Costa Paz Andréia¹²,Chaves Bárbara Aparecida¹²³^ORCID,Godoy Raquel Soares Maia³⁴^ORCID,Coelho Deilane Ferreira¹,Vieira Júnior Ademir Bentes¹²,Alencar Rodrigo Maciel¹²^ORCID,Alcântara João Arthur¹²^ORCID,Félix Luiza dos Santos³⁴,Oliveira Cinthia Catharina Azevedo³⁴^ORCID,Monteiro Wuelton Marcelo¹²^ORCID,Lacerda Marcus Vinicius Guimarães¹²⁵⁶^ORCID,Secundino Nágila Francinete Costa¹²³⁴,Pimenta Paulo Filemon Paolucci¹²³⁴

Affiliation:

1. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus 69040-000, Amazonas, Brazil

2. Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Amazonas, Brazil

3. Instituto René Rachou, Fundação Oswaldo Cruz, Fiocruz, IOCRUZ, Belo Horizonte 30190-002, Minas Gerais, Brazil

4. Programa de Pós-Graduação em Ciências da Saúde, Fiocruz, IOCRUZ, Belo Horizonte 30190-002, Minas Gerais, Brazil

5. Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz, Fiocruz, Manaus 79057-070, Amazonas, Brazil

6. Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA

Abstract

Zika virus (ZIKV) is transmitted to humans by the infectious bite of mosquitoes such as Aedes aegypti. In a city, the population control of mosquitoes is carried out according to alerts generated by different districts via the analysis of the mosquito index. However, we do not know whether, besides mosquito abundance, the susceptibility of mosquitoes could also diverge among districts and thus impact the dissemination and transmission of arboviruses. After a viremic blood meal, the virus must infect the midgut, disseminate to tissues, and reach the salivary gland to be transmitted to a vertebrate host. This study evaluated the patterns of ZIKV infection in the Ae. aegypti field populations of a city. The disseminated infection rate, viral transmission rate, and transmission efficiency were measured using quantitative PCR at 14 days post-infection. The results showed that all Ae. aegypti populations had individuals susceptible to ZIKV infection and able to transmit the virus. The infection parameters showed that the geographical area of origin of the Ae. aegypti influences its vector competence for ZIKV transmission.

Funder

Amazonas State Research Support Foundations

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

Link

https://www.mdpi.com/1999-4915/15/3/770/pdf

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