Portal Vein Thrombosis in the Setting of Cirrhosis: A Comprehensive Review

Author:

Odriozola Aitor,Puente Ángela,Cuadrado AntonioORCID,Rivas Coral,Anton Ángela,González Francisco José,Pellón Raúl,Fábrega EmilioORCID,Crespo JavierORCID,Fortea José Ignacio

Abstract

Portal vein thrombosis constitutes the most common thrombotic event in patients with cirrhosis, with increased rates in the setting of advanced liver disease. Despite being a well-known complication of cirrhosis, the contribution of portal vein thrombosis to hepatic decompensation and overall mortality is still a matter of debate. The incorporation of direct oral anticoagulants and new radiological techniques for portal vein recanalization have expanded our therapeutic arsenal. However, the lack of large prospective observational studies and randomized trials explain the heterogenous diagnostic and therapeutic recommendations of current guidelines. This article seeks to make a comprehensive review of the pathophysiology, clinical features, diagnosis, and treatment of portal vein thrombosis in patients with cirrhosis.

Funder

Carlos III Health Institute

Spanish Association for Study of the Liver

Publisher

MDPI AG

Subject

General Medicine

Reference174 articles.

1. EASL Clinical Practice Guidelines: Vascular diseases of the liver. J. Hepatol., 2016. 64.

2. ACG Clinical Guideline: Disorders of the Hepatic and Mesenteric Circulation;Simonetto;Am. J. Gastroenterol.,2020

3. Vascular Liver Disorders, Portal Vein Thrombosis, and Procedural Bleeding in Patients With Liver Disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases;Northup;Hepatology,2021

4. Baveno VII - Renewing consensus in portal hypertension;de Franchis;J. Hepatol.,2022

5. Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: Results of a case-control study;Janssen;Blood,2000

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3