Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

Author:

Jones John G.ORCID

Abstract

The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and systemic metabolic diseases as well as the disposition of medications. As a tool to better understand liver metabolism in these settings, in vivo magnetic resonance spectroscopy (MRS) offers a non-invasive means of monitoring hepatic metabolic activity in real time both by direct observation of concentrations and dynamics of specific metabolites as well as by observation of their enrichment by stable isotope tracers. This review summarizes the applications and advances in human liver metabolic studies by in vivo MRS over the past 35 years and discusses future directions and opportunities that will be opened by the development of ultra-high field MR systems and by hyperpolarized stable isotope tracers.

Funder

Fundação para a Ciência e Tecnologia

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Methods of radiology in the diagnostics of chronic liver diseases;Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH);2024-03-10

2. Interleaved trinuclear MRS for single‐session investigation of carbohydrate and lipid metabolism in human liver at 7T;NMR in Biomedicine;2024-02-29

3. Energy deficit in surgery on the examples of cholestasis and massive liver resection;Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery;2023-12-12

4. Hepatic expression of sodium–glucose cotransporter 2 (SGLT2) in patients with chronic liver disease;Medical Molecular Morphology;2022-09-21

5. 6. Methods of Abdominal MR Spectroscopy and Future Prospects;Japanese Journal of Radiological Technology;2022-02-20

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