Rectus Femoris Cross-Sectional Area and Phase Angle asPredictors of 12-Month Mortality in Idiopathic Pulmonary Fibrosis Patients
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Published:2023-10-22
Issue:20
Volume:15
Page:4473
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ISSN:2072-6643
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Container-title:Nutrients
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language:en
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Short-container-title:Nutrients
Author:
Fernández-Jiménez Rocío1234ORCID, Cabrera Cesar Eva25, Sánchez García Ana2, Espíldora Hernández Francisco6, Vegas-Aguilar Isabel M.12, Amaya-Campos Maria del Mar12, Cornejo-Pareja Isabel127ORCID, Guirado-Peláez Patricia12, Simón-Frapolli Victor123, Murri Mora278ORCID, Garrido-Sánchez Lourdes2, Martínez Mesa Alvaro5, Piñel-Jimenez Lorena5, Benítez-Cano Gamonoso Miguel5, Dalla-Rovere Lara34, García Olivares Maria2349ORCID, Velasco-Garrido Jose Luis5, Tinahones-Madueño Francisco7, García-Almeida José Manuel1247ORCID
Affiliation:
1. Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010 Malaga, Spain 2. IBIMA, Málaga Biomedical Research Institute and BIONAND Platform, 29010 Malaga, Spain 3. Department of Medicine and Dermatology, Málaga University, 29016 Malaga, Spain 4. Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, Av. Imperio Argentina, 29004 Malaga, Spain 5. Department of Neumology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain 6. Department of Neumology, Regional University Hospital, 29010 Malaga, Spain 7. Department of Endocrinology and Nutrition, Hospital Universitario Virgen de la Victoria, CIBEROBN, Carlos III Health Institute (ISCIII), University of Málaga, 29016 Malaga, Spain 8. Heart Area Clinical Management Unit, Virgen de la Victoria University Hospital, 29010 Malaga, Spain 9. Department of Endocrinology and Nutrition, Carlos de Haya Regional University Hospital, 29010 Malaga, Spain
Abstract
Background: The value of the phase angle (PhA), measured via bioelectrical impedance analysis (BIA), could be considered a good marker of the cell mass and the cell damage of a patient; however, there are new techniques, such as muscle ultrasonography, that allow the quantity and quality of muscle to be assessed in a minimally invasive way. The aim of this study is to determine the prognostic value of morphofunctional techniques in the prognosis of mortality in patients with idiopathic pulmonary fibrosis (IPF). Methods: This multicenter, cross-sectional study included 86 patients with idiopathic pulmonary fibrosis with a mean age of 71 years, 82.7% of whom were male. The nutritional risk of the patients was assessed by means of questionnaires, such as the Subjective Global Assessment (SGA), and non-invasive functional techniques, including BIA, nutritional ultrasound, and hand grip strength (HGS). Statistical analysis of the sample was performed using JAMOVI version 2.3.22. Results: Correlations were made between the RF-CSA techniques with PhA (r = 0.48, p < 0.001), BCM (r = 0.70, p < 0.001), SMI (r = 0.64, p < 0.001), and HGS (r = 0.54, p < 0.001). The cut-off points for 12-month mortality were PhA = 4.5° (AUC = 0.722, sensitivity of 72.7% and specificity of 66.6%), BCM = 28.8 kg (AUC = 0.609, sensitivity of 32.4% and specificity of 100.0%), RF-CSA = 3.00 cm2 (AUC = 0.857, sensitivity of 64.4% and specificity of 100.0%), 6MMW = 420 m (AUC = 0.830, sensitivity of 63.27% and specificity of 100.0%), and TUG = 7.2 s (AUC = 0.771, sensitivity of 100.0% and specificity of 56.67%). In addition, a multivariate analysis was performed with RF-CSA, HR = 8.11 (1.39–47.16, p = 0.020), and PhA of 6.35 (1.29–31.15, p = 0.023), taking into account age, sex, and BMI to determine mortality. Finally, a Kaplan–Meier survival analysis was conducted with low or normal values for classical parameters (GAP and T6MM) and new parameters (PhA, BCM, RF-CSA, and TUG). Conclusion: RF-CSA and PhA were shown to be good prognostic markers of 12-month mortality and could, therefore, be useful screening tools to complement the nutritional assessment of IPF patients.
Subject
Food Science,Nutrition and Dietetics
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