Corneal Neurotization—Indications, Surgical Techniques and Outcomes

Author:

Dragnea Diana Carmen1ORCID,Krolo Iva1,Koppen Carina12,Faris Callum3,Van den Bogerd Bert4,Ní Dhubhghaill Sorcha12

Affiliation:

1. Department of Ophthalmology, Antwerp University Hospital, 2650 Edegem, Belgium

2. Department of Medicine, University of Antwerp, 2610 Wilrijk, Belgium

3. Department of Otolaryngology, Antwerp University Hospital, 2650 Edegem, Belgium

4. Antwerp Research Group for Ocular Science (ARGOS), Department of Translational Neurosciences, University of Antwerp, 2610 Wilrijk, Belgium

Abstract

Corneal neurotization is a promising surgical approach for the treatment of moderate to severe neurotrophic keratopathy. This technique aims to restore corneal sensation by transferring healthy nerves, either directly or via a conduit, to the anesthetic cornea. This review provides a report on the current state of development, evidence, and experience in the field. We summarize the data available from clinical reports and case series, placing an emphasis on the diversity of the surgical techniques reported. While these data are encouraging, they also highlight the need for a consensus in reporting outcomes and highlight how the next step will involve validating putative outcome parameters when researching and reporting corneal neurotization surgery.

Publisher

MDPI AG

Subject

General Medicine

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