Overestimation of Oxygen Saturation Measured by Pulse Oximetry in Hypoxemia. Part 1: Effect of Optical Pathlengths-Ratio Increase

Author:

Elron Eyal1ORCID,Bromiker Ruben12,Gleisner Ori3,Yosef-Hai Ohad3,Goldberg Ori124,Nitzan Itamar56,Nitzan Meir3

Affiliation:

1. Neonatal Intensive Care Unit, Schneider Children’s Medical Center, Petah Tikva 4920235, Israel

2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel

3. Lev Academic Center, Jerusalem 9116001, Israel

4. Pediatric Pulmonology Institute, Schneider Children’s Medical Center, Petach Tikva 4920235, Israel

5. Shaare Zedek Medical Center, Jerusalem 9103102, Israel

6. Department of Pediatrics, Hebrew University of Jerusalem Medical School, Jerusalem 9112102, Israel

Abstract

On average, arterial oxygen saturation measured by pulse oximetry (SpO2) is higher in hypoxemia than the true oxygen saturation measured invasively (SaO2), thereby increasing the risk of occult hypoxemia. In the current article, measurements of SpO2 on 17 cyanotic newborns were performed by means of a Nellcor pulse oximeter (POx), based on light with two wavelengths in the red and infrared regions (660 and 900 nm), and by means of a novel POx, based on two wavelengths in the infrared region (761 and 820 nm). The SpO2 readings from the two POxs showed higher values than the invasive SaO2 readings, and the disparity increased with decreasing SaO2. SpO2 measured using the two infrared wavelengths showed better correlation with SaO2 than SpO2 measured using the red and infrared wavelengths. After appropriate calibration, the standard deviation of the individual SpO2−SaO2 differences for the two-infrared POx was smaller (3.6%) than that for the red and infrared POx (6.5%, p < 0.05). The overestimation of SpO2 readings in hypoxemia was explained by the increase in hypoxemia of the optical pathlengths-ratio between the two wavelengths. The two-infrared POx can reduce the overestimation of SpO2 measurement in hypoxemia and the consequent risk of occult hypoxemia, owing to its smaller increase in pathlengths-ratio in hypoxemia.

Publisher

MDPI AG

Subject

Electrical and Electronic Engineering,Biochemistry,Instrumentation,Atomic and Molecular Physics, and Optics,Analytical Chemistry

Reference46 articles.

1. Pulse oximetry: Fundamentals and technology update;Nitzan;Med. Devices,2014

2. (2022, July 26). Pulse Oximeter Accuracy and Limitations: FDA Safety Communication. Issued: February 19, 2021, Available online: https://www.fda.gov/medical-devices/safety-communications/pulse-oximeter-accuracy-and-limitations-fda-safety-communication.

3. Wilson, B.J., Cowan, H.J., Lord, J.A., Zuege, D.J., and Zygun, D.A. (2010). The accuracy of pulse oximetry in emergency department patients with severe sepsis and septic shock: A retrospective cohort study. BMC Emerg. Med., 10.

4. Accuracy of pulse oximeters at low oxygen saturations in children with congenital cyanotic heart disease: An observational study;Kim;Paediatr. Anaesth.,2019

5. Accuracy of Pulse Oximeters Intended for Hypoxemic Pediatric Patients;Harris;Pediatr. Crit. Care Med.,2016

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3