Liver and Inflammatory Biomarkers Are Related to High Mortality in Hospitalized Patients with COVID-19 in Brazilian Amazon Region-Reference-Cited by-同舟云学术

Liver and Inflammatory Biomarkers Are Related to High Mortality in Hospitalized Patients with COVID-19 in Brazilian Amazon Region

Published:2024-07-11 Issue:7 Volume:14 Page:869
ISSN:2075-1729
Container-title:Life
language:en
Short-container-title:Life

Author:

Silva Carla Sousa da¹²,Martinelli Katrini Guidolini³^ORCID,Viana Marlison Wesley Miranda⁴,Soares Deliane dos Santos⁵,Corrêa Yasmin Garcia Silva⁶,Silva Lucas Lima da²,Paula Vanessa Salete de⁷,Rodrigues Luana Lorena Silva¹⁸^ORCID,Villar Livia Melo²^ORCID

Affiliation:

1. Programa de Pós-Graduação em Ciências da Saúde, Instituto de Saúde Coletiva, Universidade Federal do Oeste do Pará (UFOPA), Santarém 66075-110, Brazil

2. Laboratório de Hepatites Virais, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro 21040-360, Brazil

3. Departamento de Medicina Social, Universidade Federal do Espírito Santo (UFES), Vitória 29040-090, Brazil

4. Curso de Enfermagem, Universidade da Amazônia (UNAMA) Campus Santarém, Santarém 68010-200, Brazil

5. Residência Multiprofissional em Estratégia Saúde da Família para as Populações do Baixo Amazonas, Instituto de Saúde Coletiva, Universidade Federal do Oeste do Pará (UFOPA), Santarém 66075-110, Brazil

6. Instituto de Biodiversidade e Florestas, Universidade Federal do Oeste do Pará (UFOPA), Santarém 66075-110, Brazil

7. Laboratório de Virologia e Parasitologia Molecular, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro 21040-360, Brazil

8. Laboratório de Aids e Imunologia Molecular, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro 21040-360, Brazil

Abstract

COVID-19 is a multisystem disease with many clinical manifestations, including liver damage and inflammation. The objective of this study is to analyze inflammation biomarkers in relation to the clinical outcome and respiratory symptoms of COVID-19. This is a retrospective cohort of patients with COVID-19 admitted to the Hospital Regional do Baixo Amazonas from 2020 to 2022. Data were collected from electronic medical records from admission to the 30th day of hospitalization and soon after hospital discharge. A total of 397 patients were included in the study. In the longitudinal follow-up of liver markers, a significant difference was found for AST on day 14, with a higher median in the death group. Among the hematological markers, lymphopenia was observed throughout the follow-up, with the death group having the most altered values. When comparing the evolution of biomarkers in the Non-Invasive Ventilation (NIV) and Invasive Mechanical Ventilation (IMV) groups, AST showed a significant difference only on day 14 and GGT on day 1, being greater in the IMV group, and indirect bilirubin on day 7 being more altered in the NIV group. In conclusion, death during hospitalization or a more severe form of COVID-19 was related to significant changes in liver and inflammatory biomarkers.

Funder

Pró-Reitoria de Pesquisa, Pós-graduação e Inovação Tecnológica—PROPPIT of Universidade Federal do Oeste do Pará, CNPq and FAPERJ

Publisher

MDPI AG

Link

https://www.mdpi.com/2075-1729/14/7/869/pdf

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