Affiliation:
1. Chemistry Department, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia
2. Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Abstract
We report the design and synthesis of novel hydroxamic acid-tethered organoselenium (OSe) hybrids. Their antimicrobial and anticancer activities were assessed against different microbes (e.g., Candida albicans (C. albicans), Escherichia coli (E. coli), and Staphylococcus aureus (S. aureus)), as well as liver and breast carcinomas. OSe hybrid 8 showed promising anticancer activity, with IC50 = 7.57 ± 0.5 µM against HepG2 and IC50 = 9.86 ± 0.7 µM against MCF-7 cells. Additionally, OSe compounds 8 and 15 exhibited promising antimicrobial activities, particularly against C. albicans (IA% = 91.7 and 83.3) and S. aureus (IA% = 90.5 and 71.4). The minimum inhibitory concentration (MIC) assay confirmed the potential antimicrobial activity of OSe compound 8. OSe compounds 8 and 16 displayed good antioxidant activities compared to vitamin C in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and the 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) assays. These results indicate that hydroxamic acid-based organoselenium hybrids have promising biological activities such as anticancer, antimicrobial, and antioxidant properties, especially compounds 8, 13, 15, and 16, which warrant further studies.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Reference51 articles.
1. Gupta, S.P. (2013). Hydroxamic Acids: A Unique Family of Chemicals with Multiple Biological Activities, Springer.
2. Synthesis, characterisation and antimicrobial evaluation of hydroxamic acid;Said;Eur. J. Biomed. Pharm. Sci.,2016
3. Antiradical, Chelating and Antioxidant Activities of Hydroxamic Acids and Hydroxyureas;Zorc;Molecules,2011
4. A Reaction of N-substituted Succinimides with Hydroxylamine as a Novel Approach to the Synthesis of Hydroxamic Acids;Tretyakov;Beilstein Arch.,2023
5. Preparation of Some Hydroxamic Acid Derivatives and Study of their Biological Activity as Anti-Cancer and Anti-Bacterial Agents;Ali;HIV Nurs.,2023
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Highly antibacterial behavior of casted films for wound dressings based on cellulose acetate containing dual compositions of ZnO and silver vanadate;Materials Chemistry and Physics;2024-09
2. New Chalcogen-Functionalized Naphthoquinones: Design, Synthesis, and Evaluation, In Vitro and In Silico, against Squamous Cell Carcinoma;ACS Omega;2024-05-08
3. Repurposed organoselenium tethered amidic acids as apoptosis inducers in melanoma cancer via P53, BAX, caspases-3, 6, 8, 9, BCL-2, MMP2, and MMP9 modulations;RSC Advances;2024
4. Synthesis of New Organoselenium-Based Succinanilic and Maleanilic Derivatives and In Silico Studies as Possible SARS-CoV-2 Main Protease Inhibitors;Inorganics;2023-07-29