The Application of Precision Medicine in Structural Heart Diseases: A Step towards the Future

Author:

Chrysostomidis Grigorios1,Apostolos Anastasios2ORCID,Papanikolaou Amalia2,Konstantinou Konstantinos3ORCID,Tsigkas Grigorios4ORCID,Koliopoulou Antigoni1,Chamogeorgakis Themistokles1

Affiliation:

1. Second Department of Adult Cardiac Surgery—Heart and Lung Transplantation, Onassis Cardiac Surgery Center, 176 74 Athens, Greece

2. First Department of Cardiology, National and Kapodistrian University of Athens, Hippocration General Hospital, 115 27 Athens, Greece

3. Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London 26504, UK

4. Department of Cardiology, University Hospital of Patras, 265 04 Patras, Greece

Abstract

The personalized applications of 3D printing in interventional cardiology and cardiac surgery represent a transformative paradigm in the management of structural heart diseases. This review underscores the pivotal role of 3D printing in enhancing procedural precision, from preoperative planning to procedural simulation, particularly in valvular heart diseases, such as aortic stenosis and mitral regurgitation. The ability to create patient-specific models contributes significantly to predicting and preventing complications like paravalvular leakage, ensuring optimal device selection, and improving outcomes. Additionally, 3D printing extends its impact beyond valvular diseases to tricuspid regurgitation and non-valvular structural heart conditions. The comprehensive synthesis of the existing literature presented here emphasizes the promising trajectory of individualized approaches facilitated by 3D printing, promising a future where tailored interventions based on precise anatomical considerations become standard practice in cardiovascular care.

Publisher

MDPI AG

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