Author:
Zhang Tingrong,Miao Shaojie,Zhang Mingxiao,Liu Wenjie,Wang Liang,Chen Yue
Abstract
We have accomplished a 10-step (longest linear) total synthesis of nannocystin A on a four hundred milligram scale. The previously reported Kobayashi vinylogous Mukaiyama aldol reaction to connect C4 and C5 was unreproducible during the scaling up process. A more convenient and cost-efficient Keck asymmetric vinylogous aldol reaction was employed to improve this transformation.
Funder
Natural Science Foundation of Tianjin City
National Natural Science Foundation of China-Guangdong Joint Fund
National Natural Science Foundation of China
National Science Fund for Distinguished Young Scholars
Subject
Drug Discovery,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science
Cited by
4 articles.
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