A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant Plantago loeflingii L.-Reference-Cited by-同舟云学术

A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant Plantago loeflingii L.

Published:2024-02-29 Issue:5 Volume:29 Page:1079
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Amin Hawraz Ibrahim M.¹²,Amin Kamaran Younis M.³,Armijos Chabaco⁴^ORCID,Hussain Faiq H. S.⁵^ORCID,Jawhar Zanko Hassan⁶,Caprioglio Diego⁷^ORCID,Mella Mariella⁸,Vidari Giovanni⁵⁸^ORCID

Affiliation:

1. Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil 44001, Iraq

2. Department of Medical Biochemical Analysis, Cihan University-Erbil, Erbil 44001, Iraq

3. Department of Chemistry, College of Education, Salahaddin University-Erbil, Erbil 44001, Iraq

4. Departamento de Química, Universidad Técnica Particular de Loja, Loja 110107, Ecuador

5. Department of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil 44001, Iraq

6. Department of Science, College of Health Science, Lebanese French University, Erbil 44001, Iraq

7. Department of Pharmaceutical Sciences, University of Eastern Piedmont, Largo Donegani 2, 28100 Novara, Italy

8. Department of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy

Abstract

A new glucosyl flavone, 5,7,2′,5′-tetrahydroxyflavone 7-O-β-d-glucopyranoside, named loeflingiin, together with apigenin 6-C-glucoside (isovitexin), coumarins citropten and isompinellin, triterpenoids betulin and betulinic acid, and a mixture of phytosterols β-sitosterol, stigmasterol and campesterol were isolated for the first time from the leaves of wild Plantago loeflingii L. (Plantaginaceae) collected in the Iraqi Kurdistan region. The plant is used by local people to treat wounds and as a vulnerary remedy. The structures of isolated compounds were determined by spectroscopic analysis. The activities of isovitexin and loeflingiinon the viability of breast (MCF7), ovarian (BG-1), endometrial (Ishikawa), and mesothelioma (IST-MES1) human cancer cells and two normal cell lines were determined with an MTT assay. Notably, the new 7-O-glucosyl flavone showed effects higher than cisplatin against the Ishikawa and IST-MESI cell lines. The significant biological activities exhibited by all the compounds isolated from P. loeflingii provided scientific evidence to support the use of the plant in the Kurdish traditional medicine.

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/5/1079/pdf

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