A New Wound-Healing Tool Based on Glycyrrhiza glabra Extract-Loaded Ufasomes on Spanish Broom Dressings-Reference-Cited by-同舟云学术

A New Wound-Healing Tool Based on Glycyrrhiza glabra Extract-Loaded Ufasomes on Spanish Broom Dressings

Published:2024-08-11 Issue:16 Volume:29 Page:3811
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Rossello Simone¹^ORCID,Mandrone Manuela²^ORCID,Cerchiara Teresa¹,Chiocchio Ilaria²^ORCID,Rossi Martina³^ORCID,Chinnici Fabio⁴^ORCID,Sallustio Valentina¹,Aponte Maria⁵^ORCID,Blaiotta Giuseppe⁵^ORCID,Luppi Barbara¹,Abruzzo Angela¹,Bigucci Federica¹,Cappadone Concettina³^ORCID

Affiliation:

1. Drug Delivery Research Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy

2. Pharmaceutical Botany Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Irnerio 42, 40127 Bologna, Italy

3. Pharmaceutical Biochemistry Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy

4. Department of Agricultural and Food Sciences, Alma Mater Studiorum, University of Bologna, Viale Fanin 40, 40127 Bologna, Italy

5. Department of Agricultural Sciences, University of Naples “Federico II”, 80055 Portici, Italy

Abstract

The development of innovative products for restoring skin integrity and promoting wound healing is still a challenge. The aim of this work was to evaluate an innovative Spanish broom wound dressing impregnated with Glycyrrhiza glabra extract-loaded ufasomes to improve wound healing. Ufasomes were characterized in terms of size, polydispersity index, entrapment efficiency, zeta potential, and stability. In addition, in vitro release studies and biocompatibility, biosafety, and scratch tests on WS1 fibroblasts were performed. The loaded ufasomes showed a nanometric size (<250 nm), good size distribution (lower than 0.3), and appropriate encapsulation efficiency (~67%). Moreover, the lipid vesicles showed good stability during the storage period and allowed for a slow release of glycyrrhizin, the main bioactive compound of the extract. Biological studies revealed that loaded vesicles are not cytotoxic, are hemocompatible, and lead to the complete closure of the scratch after about 33 h. To conclude, the results suggest that the developed dressings can be efficiently used to promote the healing process.

Funder

European Union NextGenerationEU

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/16/3811/pdf

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