Author:
Kokel Anne,Kadish Dora,Török Béla
Abstract
The chemo/regioselective H-D exchange of amino acids and synthetic building blocks by an environmentally benign Pd/C-Al-D2O catalytic system is described. Due to the importance of isotope labeled compounds in medicinal chemistry and structural biology, notably their use as improved drug candidates and biological probes, the efficient and selective deuteration methods are of great interest. The approach is based on selective H-D exchange reactions where the deuterium source is simple D2O. D2 gas is generated in situ from the reaction of aluminum and D2O, while the commercially available palladium catalyst assists the H-D exchange reaction. The high selectivity and efficiency, as well as the simplicity and safe nature of the procedure make this method an environmentally benign alternative to current alternatives.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference40 articles.
1. Effect of Deuterium Substitution in Sympathomimetic Amines on Adrenergic Responses
2. A Decade of Deuteration in Medicinal Chemistry;Liu;Annu. Rep. Med. Chem.,2017
3. Alkaloids from the mangrove endophytic fungus Diaporthe phaseolorum SKS019;Pang;Bioorg. Med. Chem. Lett.,2017
4. Deuterated drugs: where are we now?
5. Tetrabenazine-d6https://www.scbt.com/scbt/product/tetrabenazine-d6
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