Antitumor and Antibacterial Activity of Ni(II), Cu(II), Ag(I), and Hg(II) Complexes with Ligand Derived from Thiosemicarbazones: Characterization and Theoretical Studies-Reference-Cited by-同舟云学术

Antitumor and Antibacterial Activity of Ni(II), Cu(II), Ag(I), and Hg(II) Complexes with Ligand Derived from Thiosemicarbazones: Characterization and Theoretical Studies

Published:2023-03-13 Issue:6 Volume:28 Page:2590
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Alshater Heba¹^ORCID,Al-Sulami Ahlam I.²,Aly Samar A.³,Abdalla Ehab M.⁴^ORCID,Sakr Mohamed A.⁵^ORCID,Hassan Safaa S.⁶

Affiliation:

1. Department of Forensic Medicine and Clinical Toxicology University Hospital, Menoufia University, Shebin El-Kom 32511, Egypt

2. Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia

3. Department of Environmental Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City 32958, Egypt

4. Chemistry Department, Faculty of Science, New Valley University, Alkharga 72511, Egypt

5. Medical Microbiology and Immunology Department, Faculty of Medicine, Suez University, Suez 41522, Egypt

6. Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt

Abstract

Four new complexes (Ni2+, Cu2+, Ag+, and Hg2+) were prepared from the ligand N-(4-chlorophenyl)-2-(phenylglycyl)hydrazine-1-carbothioamide (H2L). Analytical and spectroscopic techniques were used to clarify the structural composition of the new chelates. In addition, all chelates were tested against bacterial strains and the HepG2 cell line to determine their antiseptic and carcinogenic properties. The Ni(II) complex was preferable to the other chelates. Molecular optimization revealed that H2L had the highest reactivity, followed by Hg-chelate, Ag-chelate, Ni-chelate, and Cu-chelate. Moreover, molecular docking was investigated against two different proteins: the ribosyltransferase enzyme (code: 3GEY) and the EGFR tyrosine kinase receptor (code: 1m17).

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/6/2590/pdf

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