Regioselective Reaction of 2-Indolylmethanols with Enamides-Reference-Cited by-同舟云学术

Regioselective Reaction of 2-Indolylmethanols with Enamides

Published:2023-04-10 Issue:8 Volume:28 Page:3341
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Tian Yuting¹,He Dongqing²,Gao Limei¹,Zou Yu¹,Liu Xiaoshuang¹,Wang Qiang¹,Liang Enxiang²,Zheng Yongsheng¹

Affiliation:

1. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China

2. Department of Chemistry and Chemical Engineering, Institute of Science and Technology, Yueyang 414000, China

Abstract

A highly regioselective reaction of 2-indolylmethanols with enamides has been developed at room temperature by using AlCl3 as a catalyst. A wide range of hybrids (40 examples) of indoles and enamides were obtained in moderate to good yields (up to 98% yield). This transformation represents the efficient way to introduce biologically important indoles and enamides skeleton into structurally complex hybrids.

Funder

National Natural Science Foundation of China

Hubei Provincial Natural Science Foundation of China

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/8/3341/pdf

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