Affiliation:
1. The University of Jeddah, College of Science, Department of Biology, Jeddah 23218, Saudi Arabia
Abstract
Viral infections are spread all around the world. Although there are available therapies, their safety and effectiveness are constrained by their adverse effects and drug resistance. Therefore, new natural antivirals have been used such as essential oils, which are natural products with promising biological activity. Accordingly, the present study aimed to identify the components of clove (Syzygium aromaticum) essential oil (EOCa) and verify its antioxidant and antiviral activity. The oil was analyzed using GC/MS, and the antioxidant capacity was evaluated as a function of the radical scavenging activity. A plaque reduction test was used to measure the antiviral activity against herpes simplex virus (HSV-1), hepatitis A virus (HAV), and an adenovirus. GC/MS analysis confirmed the presence of eugenol as the main component (76.78%). Moreover, EOCa had powerful antioxidant activity with an IC50 of 50 µg/mL. The highest antiviral potential was found against HAV, with a selectivity index (SI) of 14.46, while showing poor selectivity toward HSV-1 with an SI value of 1.44. However, no relevant effect was detected against the adenovirus. The antiviral activity against HAV revealed that its effect was not related to host cytotoxicity. The findings imply that EOCa can be utilized to treat diseases caused by infections and free radicals.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference55 articles.
1. Hafidh, R., Abdulamir, A., Abu Bakar, F., Sekawi, Z., Jahansheri, F., and Jalilian, F. (2015). Novel antiviral activity of mung bean sprouts against respiratory syncytial virus and herpes simplex virus −1: An in vitro study on virally infected Vero and MRC-5 cells lines. BMC Complement. Altern. Med., 15.
2. Evaluation of antiviral activity of essential oil of Trachyspermum Ammi against Japanese encephalitis virus;Roy;Pharmacogn. Res.,2015
3. Phytochemistry and pharmacological aspects of Syzygium aromaticum: A review;Kaur;J. Pharmacogn. Phytochem.,2019
4. Stringaro, A., Colone, M., and Angiolella, L. (2018). Antioxidant, antifungal, antibiofilm, and cytotoxic activities of Mentha spp. essential oils. Medicines, 5.
5. An updated and comprehensive review of the antiviral potential of essential oils and their chemical constituents with special focus on their mechanism of action against various Influenza and Coronaviruses;Wani;Microb. Pathog.,2021
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献