Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand

Author:

Liang Xiaoqin12,Niu Peng1,Li Jun2,Guan Xinlan3,Zhang Yanjun1,Li Jian3

Affiliation:

1. Guangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535000, China

2. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemical & Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China

3. Peoples’ Hospital of Pubei, Qinzhou 535300, China

Abstract

Two new triterpenoid glucosides, Heritiera A (1) and Heritiera B (2), and six known triterpenoid analogs (3–8) were isolated from Heritiera littoralis Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from H. littoralis was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound 2 substantially inhibits the release of nitric oxide (NO) with an IC50 value of 10.33 μM. The triterpenoids from H. littoralis could be used as potential candidates for the development of new anti-inflammatory agents.

Funder

Natural Science Foundation of Guangxi Province

Research project of Beibu Gulf University

Marine Science First-Class Subject, Beibu Gulf University

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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